A*STAR

Scientist II (Molecular Diagnostics), DxD Hub

A*STAR
ResearchSingaporeOnsitePosted 3 days ago

About the role

AI summarised

Mid-level scientist role focused on developing regulated clinical diagnostic products, particularly nucleic acid-based testing using NGS and PCR technologies. Involves leading assay development from concept through clinical validation while managing cross-functional projects and mentoring junior staff.

ResearchOnsiteDiagnostics Development Hub

Key Responsibilities

  • Contribute to molecular test assay method development, analytical verification and clinical validation study design, planning and execution in compliance with regulatory and quality standards
  • Contribute to the study results data curation and data analysis for downstream molecular test assay application
  • Lead project teams to ensure the successful delivery of molecular diagnostics development milestones, leveraging effective project planning, resource management, and risk mitigation strategies
  • Establish, manage, and monitor project plans, timelines, budgets, and deliverables, ensuring alignment with regulatory requirements, quality standards, and company objectives
  • Facilitate regular project meetings, document minutes and action items, and communicate progress transparently to internal and external stakeholders
  • Identify and resolve project bottlenecks, technical risks, and resource gaps, escalating issues as needed to management
  • Contribute to clinical study design and clinical trial in regulated diagnostic product settings
  • Contribute to product landscape study on safety dossier and technical note approved by regulators
  • Responsible for mentoring junior scientists and refresher on the latest technology development and product landscape
  • Responsible for good record-keeping and standard operating procedures (SOPs) implementation in accordance with confidential information requirement, quality system and regulatory guidelines

Requirements

  • Education in Molecular Biology, Cell Biology, Biochemistry, Genomics, Biotechnology, or a related field
  • 3-5 years of hands-on experience in molecular assay development, preferably in industrial, diagnostics or clinical laboratory setting using platforms such as NGS or PCR/qPCR technologies
  • Laboratory skills in pre-analytical and analytical techniques, including extensive knowledge and hands-on experience in molecular techniques and platforms including nucleic acid extraction, PCR/qPCR, NGS, isothermal amplification and CRISPR-based diagnostic tools
  • Strong scientific foundation, demonstrated critical thinking abilities, and proven experience applying first-principles methodology
  • Strong track record in experimental design, troubleshooting, and optimisation of laboratory workflows
  • Project management experience in a laboratory, clinical or diagnostic product development context
  • Familiarity with regulatory and quality standards for diagnostic assay development e.g. ISO13485 is advantageous