About the role
AI summarisedMid-level bench scientist role focused on designing and synthesizing ligand-oligonucleotide conjugates for targeted extrahepatic RNA delivery. The position involves hands-on bioconjugation chemistry, analytical characterization, and cross-functional collaboration to advance RNA therapeutics from discovery toward clinical development.
ResearchOnsite
Key Responsibilities
- Design and execute conjugation strategies to generate LOCs with optimized delivery profiles
- Collaborate closely with oligonucleotide chemists, biologists, and pharmacologists to evaluate LOCs in vitro and in vivo
- Support CRO coordination and reagent sourcing for ligand libraries and conjugation reagents
- Ensure reproducibility and analytical rigor across experimental workflows
- Maintain high-quality documentation of experimental procedures, results, and data interpretation
- Contribute to innovation and IP generation through novel conjugation approaches and delivery strategies
- Present findings in internal meetings and contribute to technical reports, publications, and patent filings
Requirements
- A doctorate degree in Chemistry, Chemical Biology, Organic/Medicinal Chemistry, or a related field
- A minimum of 2-6 years of relevant industry experience in bioconjugation chemistry applied to LOCs, ADCs, PDCs, or targeted delivery systems
- Hands-on experience establishing conjugation chemistries (e.g., Click, lysine-/cysteine-based coupling, enzymatic ligation, stimuli-sensitive linkers) workflows for development of LOCs
- Hands-on experience with multiscale purification methods (e.g., preparative RP-HPLC, affinity, ion-exchange, hydrophobic interaction, and size exclusion chromatography, tangential flow filtration) and the associated instruments
- Deep understanding of analytical techniques (e.g., LC-MS, LC-HRMS, CE-SDS, DSC, HIC, NMR) coupled with hands-on experience developing analytical workflows for robust characterization of LOCs
- Experience coordinating with CROs and cross-functional program leadership
- Demonstrated innovation through IP, publications, IND filings, or other public disclosures
- Excellent organizational, interpersonal, and verbal/written communication skills