About the role
AI summarisedThe Senior Scientist will lead target discovery and validation for RNA‑based therapeutics addressing metabolic and cardiovascular diseases such as MASH, obesity, and muscle disorders. The role involves integrating multi‑omics and human genetics data, guiding cross‑functional teams, and delivering validated target dossiers for pipeline advancement.
ResearchOnsite
Key Responsibilities
- Lead Target Discovery: Own and advance a rolling portfolio of genetically and mechanistically supported targets for RNA therapeutics in MASH, obesity, and skeletal muscle related metabolic disorders
- Translate Human Data into Actionable Biology: Integrate human genetics and multi omics datasets to generate clear, testable hypotheses, mechanistic rationales, and strategies
- Decision-Grade Target Selection: Establish and apply a standardised target ranking framework that supports transparent go / no‑go decisions
- Cross-Functional Leadership: Serve as the scientific decision owner for target discovery, aligning bioinformatics, biology, and pharmacology teams around shared milestones
- Define and Execute Target Enablement & Validation Strategies: Design and oversee fit‑for‑purpose validation plans using human‑relevant models and RNA compatible approaches
- Define disease‑relevant biological questions in MASH and obesity or musculoskeletal disorders
Requirements
- PhD in Biology, Genetics or related discipline
- 5+ years of experience in target discovery or human genetics (10+ years for Senior Scientist)
- Proven expertise in multi‑omic data interpretation and integration
- Strong background in metabolic disease biology especially MASH and obesity
- Experience working with bioinformaticians and computational biologists on large datasets
- Track record of identating identifying identifying