About the role
AI summarisedResearch Officer position in a lab focused on therapeutic target discovery for metabolic dysfunction-associated steatotic liver disease (MASLD), using siRNA-based therapeutics and integrating multi-omics datasets with in vivo and in vitro models. The role involves molecular biology, cell culture, and potentially animal work to validate therapeutic targets.
ResearchFull-timeGenome Institute of Singapore
Key Responsibilities
- Conduct therapeutic target discovery and translational development for metabolic dysfunction-associated steatotic liver disease (MASLD)
- Integrate patient-derived multi-omics datasets with in vivo functional genetic screening and human in vitro disease models
- Systematically identify and validate clinically relevant therapeutic targets
- Perform molecular biology and mammalian cell culture experiments
- Utilize hepatocyte models and RNA-based techniques
- Conduct animal work including mouse handling, injections, and tissue collection
- Maintain strong organizational and problem-solving skills in a fast-paced environment
- Work independently and collaboratively within the research team
Requirements
- Bachelor's or Master's degree in Biomedical Sciences or related fields
- Prior experience in molecular biology and mammalian cell culture
- Experience with hepatocyte models, metabolic disease, or RNA-based techniques is advantageous
- Experience with animal work (mouse handling, injections, tissue collection) is a plus
- Strong organizational and problem-solving skills
- Ability to work independently and collaboratively in a fast-paced environment
- Experience in liver disease or metabolic disease research (preferred)
- Experience with siRNA or gene knockdown approaches (preferred)
- Familiarity with histology or imaging-based assays (preferred)
- Experience working in translational or interdisciplinary research settings (preferred)