A*STAR

Scientist, Project GLOW (GIS)

A*STAR
ResearchSingaporeFull-time3 weeks ago

About the role

AI summarised

The Scientist will work on Project GLOW, a population-scale study in Singapore focusing on the gut microbiome and mental health, using advanced metagenomics and metabolomics. The role involves developing computational methods for genome-resolved metagenomics, intra-host diversity analysis, and host-microbe interaction studies. The position is based at the Genome Institute of Singapore (GIS) and NUS.

ResearchFull-timeGenome Institute of Singapore

Key Responsibilities

  • Conduct population-scale study (>5,000 participants) on microbiome and mental health
  • Leverage long-read metagenomics (PacBio HiFi, ONT, CycloneSeq) and untargeted metabolomics
  • Integrate host multi-omics datasets and deep phenotyping (particularly mental health-related)
  • Study how gut microbes impact mental well-being
  • Develop next-generation computational methods for genome-resolved metagenomics
  • Perform intra-host diversity analysis and strain-level phenotypic associations
  • Conduct metagenome-scale metabolic modelling and host-microbe interaction studies

Requirements

  • PhD in Computational Metagenomics
  • Strong publication track record
  • Significant experience in algorithm development (preferred)