About the role
AI summarisedThis role is for a Research Officer in a biotech research environment, focusing on developing advanced human skin models for regenerative medicine and therapeutic testing. The candidate will conduct experimental research involving 3D skin model development, cell culture, gene editing, and tissue characterization.
ResearchFull-timeA*STAR Skin Research Labs
Key Responsibilities
- Carry out experimental research related to 3D skin model development, including hiPSC cell culture, isolation, culture, and differentiation of human immune cells, gene editing and 3D tissue culture within microfluidic devices.
- Integrate epithelial, stromal, vascular, and immune components into advanced tissue models.
- Perform tissue processing and characterization using techniques such as histology, immunostaining, fluorescence and confocal microscopy, qPCR, flow cytometry and multi-omics.
- Generate reproducible high-quality data, perform data analysis, prepare figures and reports, and review relevant scientific literature.
- Support general laboratory operations, including maintaining proper documentation of experiments, preparation of risk assessments, ensuring compliance with laboratory safety procedures, inventory management, and other administrative duties as required.
Requirements
- Degree in Biological Sciences, Life Sciences, Biomedical Engineering, Bioengineering, or a related discipline.
- Relevant hands-on experience in cell culture and 3D tissue model development and validation.
- Experience with organ-on-a-chip platforms, and vascularized tissue models.
- Proficiency in microscopy-based analysis, including confocal imaging; experience with high-content imaging.
- Experience in histology, immunohistochemistry/immunofluorescence, and tissue characterization techniques.
- Familiarity with molecular biology techniques and 3D cell-based functional assays.
- Experience in skin biology, vascular biology and immunology would be an advantage.
- Excellent organizational skills, with the ability to work independently and manage multiple tasks effectively.
- Strong interpersonal and communication skills.
- Careful, precise, and goal-oriented approach to experimental work.
- Strong motivation, commitment to research excellence, and willingness to learn and troubleshoot new procedures.
- A collaborative mindset and the ability to work effectively in an interdisciplinary team.