About the role
AI summarisedJoin NATi, Singapore's national platform for nucleic acid therapeutics, to drive the discovery and validation of novel targets for RNA-based medicines addressing MASH, obesity, and skeletal muscle metabolic disorders. This senior role requires deep expertise in human disease biology, multi-omics integration, and translational science to translate complex human data into actionable targets for siRNA/ASO development.
ResearchOnsite
Key Responsibilities
- Own and advance a rolling portfolio of genetically and mechanistically supported targets for RNA therapeutics in MASH, obesity, and skeletal muscle related metabolic disorders.
- Integrate human genetics and multi-omics datasets to generate clear, testable hypotheses and mechanistic rationales linking target modulation to clinically meaningful outcomes.
- Establish and apply a standardized target ranking framework to support transparent go/no-go decisions regarding therapeutic targets.
- Serve as the scientific decision owner for target discovery, aligning bioinformatics, biology, and pharmacology teams around shared milestones.
- Design and oversee fit-for-purpose validation plans using human relevant models to generate decision-enabling data for advancement or deprioritization.
- Define disease-relevant biological questions in MASH, obesity, and/or musculoskeletal disorders that guide data interrogation.
Requirements
- PhD in Biology, Genetics, Genomics, Bioinformatics, Pharmacology, or related discipline.
- Minimum of 10+ years of relevant experience in target discovery, human genetics, or translational disease biology in pharmaceutical/biotech organizations.
- Proven expertise in multi-omic data interpretation and integration for complex human diseases.
- Strong background in metabolic disease biology, particularly MASH, obesity, and/or skeletal muscle disorders.
- Demonstrated experience collaborating with bioinformaticians and computational biologists on large datasets.
- Track record of identifying, prioritizing, and enabling novel therapeutic targets.
- Strategic, hypothesis-driven thinker with excellent scientific communication skills.