About the role
AI summarisedLead Research Officer in Translational Neuroscience at A*STAR IHDP, focusing on genetic and environmental influences on child brain health. The role involves developing bioinformatics approaches, conducting GWAS and PRS analyses, and working in interdisciplinary teams to advance mental health research.
ResearchFull-time
Key Responsibilities
- Develop and apply appropriate approaches for quantifying and correcting for biases in genomics data
- Advancing bioinformatics and statistical analyses related to genetics and environmental influences on child outcomes, including genome-wide association studies (GWAS), whole-genome sequencing (WGS) analysis, fine-mapping, and rare variant analysis, and polygenic risk score (PRS) creation
- Developing and validating risk prediction models, specifically utilizing PRS to tailor disease screening and prevention strategies, often in a clinical or primary care setting.
- Scripting and automating robust analysis pipelines to query, retrieve and analyse information in the dataset
- Working within interdisciplinary teams of researchers and presenting work in progress, preparing reports, and contributing to manuscripts for peer-reviewed publications and grant application
Requirements
- PhD degree in bioinformatics, statistical genetics, human genetics, computer science or related field, or Master in related fields with relevant experience in genetics or other complex biological.
- Track record of experience and training in biological data, data analyses and data mining on genomic datasets.
- Demonstrate strong understanding of bioinformatics approaches such as genetic associations, polygenic risk scores.
- Strong programming skills in Unix and at least R and/or Python.
- Proficient with statistical analysis and experience in advanced computational methods (e.g., machine learning) would be advantageous.
- Excellent written, communication and organizational skills, with experience working independently and in multi-disciplinary teams.