About the role
AI summarisedJoin the Genome Institute of Singapore (GIS) in a multi-institutional effort to develop an end-to-end platform for novel RNA target identification and small-molecule discovery for cancer therapeutics. This role integrates RNA structural biology, functional genomics, and chemical biology to uncover and exploit RNA vulnerabilities in cancer.
ResearchOnsiteGenome Institute of Singapore
Key Responsibilities
- Lead the design and execution of experiments to identify structurally defined RNA regulatory elements in cancer and functionally validate RNA targets using genetic and molecular perturbation approaches.
- Interpret complex multi-omic datasets to generate testable biological hypotheses regarding cancer drivers and therapeutic strategies.
- Provide scientific leadership by proposing innovative directions, refining research strategy, and ensuring scientific rigor across the discovery pipeline.
- Mentor research officers to foster a collaborative and high-performing research environment.
- Prepare high-impact manuscripts and contribute to intellectual property generation arising from programme discoveries.
- Present research findings at internal reviews, conferences, and to academic and industry stakeholders.
- Coordinate and integrate activities across work packages, ensuring scientific alignment and timely execution of the discovery platform.
- Track programme progress against milestones and proactively identify risks, bottlenecks, and mitigation strategies.
Requirements
- PhD in molecular biology, genomics, RNA biology, cancer biology, or a related field.
- Experience with molecular biology techniques (e.g., Cell culture, Transfection/Transduction, Western Blot, qPCR, Molecular cloning).
- Experience with Next Generation Sequencing (NGS) techniques.
- Strong track record of peer-reviewed publications.
- Highly motivated and demonstrated ability to work in collaborative, interdisciplinary teams.