About the role
AI summarisedJoin NATi, Singapore's national platform for nucleic acid therapeutics, to advance next-generation mRNA immunotherapies. This role involves driving the development of immunotherapy candidates from discovery/pre-clinical stages through to IND-enabling studies, requiring deep translational expertise in immunology and vaccinology.
ResearchOnsite
Key Responsibilities
- Support and execute the Vaccines R&D strategy in an innovative manner.
- Develop and optimize laboratory methods for characterizing RNA therapeutic modalities (mRNA, circRNA, saRNA, gRNA), focusing on protein translation and stability.
- Design and conduct in vitro assays to assess vaccine-specific responses, identifying cellular targets and efficacy readouts for infectious diseases.
- Independently write protocols, procedures, and develop/maintain SOPs ensuring reproducibility for IND submission and contributing to CMC documentation.
- Prepare technical reports, presentations, and documentation supporting internal decision-making and external regulatory submissions.
- Collaborate with scientists across multiple functions and maintain accurate records using LIMS/ELN systems.
Requirements
- PhD in Immunology or a related field with minimum 8+ years of experience.
- Detailed knowledge in immunology and cellular biology, including T-cell function, cytokine signaling, tolerance mechanisms, and immunopathology.
- Proven proficiency in immunophenotyping, including extensive hands-on experience with multi-color flow cytometry (panel design, staining, compensation, data analysis).
- Strong track record in advancing immunology-focused therapeutics and leading translational/biomarker initiatives.
- Proven ability to develop, validate, and troubleshoot assays.
- Ability to work independently and collaboratively in a fast-paced multidisciplinary environment.
- Knowledge and experience with in vivo models.